How is progeria treated
Progeria Type I (HGPS): Therapy
Next update of Astrid Clasen • Medical editor
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In the case of progeria type I (HGPS), causal therapy is not possible, the disease is incurable. Symptomatic treatment can, however Relieve discomfort and Prevent complications:
- For example strengthens physical therapy the muscles, improves blood circulation and prevents stiff joints.
- Bath additives or lotions help protect sensitive skin.
- Provide contact and exchange with other affected parties emotional support and strengthen self-esteem.
All of these measures improve the quality of life of children with progeria type I.
Currently, among other things two medicines researched that are already used to treat other diseases:
For a few years, doctors have been testing these drugs in combination with another drug, a so-called Farnesyl transferase inhibitor (FTI) - initially on cell cultures and mice. Studies on mice have shown that FTIs in particular have the Symptoms Progeria such as hardening of the arteries (arteriosclerosis) delay and thus can increase life expectancy.
In the meantime, the farnesyl transferase inhibitor for progeria therapy has also been tested on children with Hutchinson-Gilford syndrome. They received the active ingredient for at least two years - with promising success. The drug produced at least one of the following improvements in the children:
- Weight gain
- better hearing
- more stable bone structure
- more elastic blood vessels
A recent study was able to show that therapy with a farnesyl transferase inhibitor also helps Life expectancy of children with progeria increased.
In some cases, doctors at HGPS also use acetylsalicylic acid for therapy. This drug works to prevent blood clots (thrombi) from forming and reduced the risk for Vascular occlusions and with them heart attacks and strokes, which are common in children with progeria.
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